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Research & Reflections

The Thinking Room

PUBLICATIONS
INSIGHTS

Our publication portfolio reflects our integrated approach to scientific engagement—where rigorous evidence meets strategic execution. These include peer-reviewed publications where we delivered medical writing support as part of client scientific engagement strategies, and scholarly contributions from our team members through previous institutional affiliations. Each demonstrates how we transform complex science into compelling communications that accelerate clinical understanding and patient access.

Insight Acceleration Post-Launch Lifecycle Infectious Disease

Incidence and Burden of Herpes Zoster in Sweden

Journal: Infect Dis Ther
Authors Södergren E, Mårdberg K, Nishimwe M, et al.

Regional population-based register study examining the incidence and disease burden of herpes zoster across Swedish populations.

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Clinical Strategy & Evidence Insight Acceleration Post-Launch Lifecycle Infectious Disease

Global Prevalence of Varicella-Associated Complications

Journal: Infect Dis Ther
Authors Shah HA, Meiwald A, Perera C, et al.

Systematic review and meta-analysis examining the global prevalence of complications associated with varicella infection.

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Market Access Post-Launch Lifecycle Rare & Orphan Diseases

Health Technology Assessment Paradigm in Rare Diseases

Journal: Value in Health
Authors Jain P, Pandey S, Ostawal A

Examines critical determinants shaping HTA frameworks for rare disease therapies and provides strategic recommendations for navigating reimbursement pathways.

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Clinical Strategy & Evidence Market Access Discovery & Early Dev Phase I/II Clinical Phase III Clinical Various

The Value of Treatment for Infertility

Journal: Best Practice & Research Clinical Obstetrics & Gynaecology
Authors Fenwick E, Eze A, Hooghe T, Pandey S, Chaudhari V, Ostawal A, Luyten J, Harty G

Systematically reviews willingness-to-pay thresholds and methodological approaches for determining cost-effectiveness of fertility therapies.

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Insight Acceleration Post-Launch Lifecycle Infectious Disease

Rotavirus Vaccine Impact in Argentina's National Immunization Program

Journal: Infect dis Ther
Authors García Martí S, Gibbons L, Reidel S, et al.

Analyzes the real-world impact of rotavirus vaccine introduction on disease burden since implementation in Argentina's national immunization program.

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Scientific Engagement Insight Acceleration Launch Preparation Post-Launch Lifecycle Infectious Disease

Herpes Zoster Disease Burden and Prevention in India

Journal: Hum Vaccin Immunother
Authors Ramasubramanian V, Vora A, Lagoubi Y, Lecrenier N, Chugh Y

Expert opinion paper examining herpes zoster disease burden and prevention strategies in the Indian healthcare context.

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Insight Acceleration Post-Launch Lifecycle Infectious Disease

Changing Patterns of Invasive Meningococcal Disease

Journal: Human Vaccines & Immunotherapeutics
Authors Taha MK, Bekkat-Berkani R, Abibol V

Analyzes evolving patterns of invasive meningococcal disease and implications for future immunization strategies.

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Market Access Launch Preparation Infectious Disease

Cost of University-Based Meningococcal Disease Outbreaks

Journal: J Am Col Health
Authors Hicks K, Ghaswalla P, Carrico J, et al.

Estimates the costs associated with university-based serogroup B meningococcal disease outbreaks under different pre-matriculation vaccination policies in the United States.

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Market Access Insight Acceleration Post-Launch Lifecycle Infectious Disease

Cost of Illness Due to Pertussis in Adults in the United Kingdom

Journal: Vaccine
Authors Versteeg JW, Jamet N, Redekop K

Economic burden study quantifying the cost of illness associated with pertussis in adults in the United Kingdom.

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Market Access Insight Acceleration Post-Launch Lifecycle Infectious Disease

Socioeconomic Status and Economic Burden of Pertussis in Adults

Journal: ISPOR-EU 2023 Conference
Authors Jamet N, Berlaimont V, Ramond A, et al.

Post-hoc analysis examining how socioeconomic status influences the economic burden of pertussis in English adults.

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Insight Acceleration Post-Launch Lifecycle Infectious Disease

Public Health Impact of Pneumococcal Vaccines in Gavi Countries

Journal: Hum Vaccin Immunother
Authors Marijam A, Schuerman L, Izurieta P, et al.

Estimates the public health impact of pneumococcal vaccines on child morbidity and mortality in Gavi-supported countries.

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Insight Acceleration Post-Launch Lifecycle Infectious Disease

Impact of COVID-19 on Childhood Vaccine Coverage in Latin America

Journal: Hum Vaccin Immunother
Authors Castrejón MM, Leal I, Pinto TJ, et al.

Systematic review examining how COVID-19 affected routine childhood vaccination coverage trends across Latin America.

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Clinical Strategy & Evidence Phase I/II Clinical Phase III Clinical Infectious Disease

Patient-Reported Outcomes in Vaccines Research

Journal: Vaccine
Authors Curran D, Cabrera ES, Nelsen L

Explores the relevance and application of patient-reported outcomes in vaccines research and clinical development.

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Clinical Strategy & Evidence Insight Acceleration Discovery & Early Dev Phase I/II Clinical Infectious Disease

Novel Approach to Scoping Review of Gonorrhoea Evidence

Journal: BMC Med Res Methodol
Authors Whelan J, Ghoniem M, Médoc N, et al.

Applies innovative methodology to scoping review of gonorrhoea evidence, mapping natural history and disease burden.

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Market Access Launch Preparation Post-Launch Lifecycle Medical Devices & Interventions

Cost-Effectiveness of iStent Inject in Open-Angle Glaucoma

Journal: PLoS One
Authors Nieland K, Labbé A, Schweitzer C, et al.

Economic evaluation of iStent inject combined with cataract surgery for treating glaucoma in France.

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Market Access Insight Acceleration Post-Launch Lifecycle Infectious Disease

Economic Burden of Pertussis Among Adults in England

Journal: ERS 2021 Conference
Authors Harrington L, Aris E, Bhavsar A, et al.

Retrospective study quantifying the economic burden of pertussis among adults aged 50+ in England.

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Insight Acceleration Post-Launch Lifecycle Infectious Disease

Can COVID-19 Increase the Risk of Herpes Zoster?

Journal: SEMG 2021 Conference
Authors Diez-Domingo J, Cisneros E, McCormick N, et al.

Narrative review examining potential links between COVID-19 infection and herpes zoster reactivation.

Clinical Strategy & Evidence Insight Acceleration Discovery & Early Dev Phase I/II Clinical Medical Devices & Interventions

Where Are We Headed with Digital Therapeutics?

Journal: Value in Health
Authors Arca E, Hartl K, Ostawal A

Systematic review examining the evidence landscape and future trajectory of digital therapeutic interventions.

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Insight Acceleration Post-Launch Lifecycle Infectious Disease

Infant Mandatory Vaccinations: Confirmation of Positive Impact

Journal: ESPID 2020 Conference
Authors Cohen R, Martinot J, Gaudelus J, et al.

Conference presentation confirming positive impact of mandatory infant vaccination policies.

Market Access Launch Preparation Infectious Disease

Epidemiological Impact of Varicella Vaccination in UK

Journal: ESPID 2020 Conference
Authors Akpo EIH, Cristeau O, Vatsa B, et al.

Evaluates epidemiological impact and cost-effectiveness of varicella vaccination strategies in the UK.

Clinical Strategy & Evidence Insight Acceleration Post-Launch Lifecycle Infectious Disease

Impact of Herpes Zoster on Quality of Life

Journal: CPHA 2020 Conference
Authors Van Oorschot D, McGirr A, Goulet P, et al.

Concept elicitation study examining how herpes zoster affects patients' quality of life.

Insight Acceleration Post-Launch Lifecycle Immunology & Inflammation

Burden of Immune-Mediated Diseases in Japan

Journal: JSCI 2020 Conference
Authors Tanaka Y, Matsuki T, Onoue T, et al.

Claims database study quantifying burden of immune-mediated diseases in Japanese populations.

Market Access Launch Preparation Cardiovascular & Metabolic

Disease Progression Capture in COPD Models

Journal: ISPOR EU 2020 Conference
Authors Molnar D, D'Souza V, Martin A

Systematic review examining how disease progression is captured in COPD economic models.

Regulatory Strategy Market Access Regulatory Submission Launch Preparation Oncology & Hematology

Joint Health Technology Assessment in Europe

Journal: Value in Health
Authors Jose R, Ostawal A, Arca E, Hartl K

Evaluates EUNetHTA joint clinical assessments versus national appraisals in oncology.

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Market Access Regulatory Submission Launch Preparation Various

Balancing Global HTA Requirements

Journal: Value in Health
Authors Ostawal A, Arcà E, Braun N, Alleman C

Strategic approaches to meeting diverse HTA literature review requirements globally.

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Scientific Engagement Insight Acceleration Post-Launch Lifecycle Infectious Disease

Implementation Science for HIV Care

Journal: PLOS ONE
Authors Cox J, Gutner C, Kronfli N, et al.

Identifies gaps to optimize adoption of evidence-based HIV interventions.

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Market Access Regulatory Submission Launch Preparation Oncology & Hematology

Country-Specific Guidelines Impact on Cost-Effectiveness

Journal: GI Cancers Symposium 2017
Authors Harty G, Fujii RK, Ostawal A, Pescott CP

How varying HTA guidelines impact cost-effectiveness using cetuximab as case study.

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Clinical Strategy & Evidence Insight Acceleration Post-Launch Lifecycle Cardiovascular & Metabolic

Clinical Effectiveness of Liraglutide in Type 2 Diabetes

Journal: Diabetes Therapy
Authors Ostawal A, Mocevic E, Kragh N, Xu W

Real-world evidence review of liraglutide clinical effectiveness in diabetes management.

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Clinical Strategy & Evidence Market Access Launch Preparation Post-Launch Lifecycle Infectious Disease

GSK Quadrivalent Influenza Vaccines Evidence Update

Journal: Expert Rev Vaccines
Authors Bekkat-Berkani R, Ray R, Jain VK, et al.

Comprehensive evidence review of GSK quadrivalent influenza vaccines.

Insight Acceleration Post-Launch Lifecycle Infectious Disease

Influenza B Circulation Patterns in Brazil

Journal: Braz J Infect Dis
Authors Barros EN, Cintra O, Rossetto E, et al.

Analyzes influenza B patterns in Brazil to inform vaccine composition strategies.

Insight Acceleration Post-Launch Lifecycle Infectious Disease

Epidemiology and Disease Burden of Influenza B in Europe

Journal: Hum Vaccin Immunother
Authors Tafalla M, Buijssen M, Geets R, et al.

Comprehensive review of influenza B epidemiology and disease burden across 9 European countries.

Market Access Launch Preparation Post-Launch Lifecycle Infectious Disease

Cost-Effectiveness of Quadrivalent Influenza Vaccines

Journal: BMC Infect Dis
Authors Thommes EW, Ismaila A, Chit A, et al.

Dynamic modeling study evaluating cost-effectiveness of quadrivalent influenza vaccines in Canada and UK.

Market Access Launch Preparation Infectious Disease

Cost-Effectiveness of Pneumococcal Vaccines in Japanese Children

Journal: Infect Dis Ther
Authors Shiragami M, Mizukami A, Leeuwenkamp O, et al.

Economic evaluation comparing 10-valent and 13-valent pneumococcal conjugate vaccines in Japan.

Market Access Launch Preparation Infectious Disease

Cost-Effectiveness of Routine Varicella Vaccination in France

Journal: Clin Ther
Authors Littlewood KJ, Ouwens MJ, Sauboin C, et al.

Economic analysis using dynamic transmission modeling to evaluate routine MMRV vaccination in France.

Clinical Strategy & Evidence Insight Acceleration Launch Preparation Post-Launch Lifecycle Infectious Disease

Impact of 2-Dose MMRV Vaccination on Varicella and Zoster

Journal: Clin Ther
Authors Ouwens M, Littlewood K, Sauboin C, et al.

Dynamic modeling study examining epidemiological impact of routine 2-dose MMRV vaccination in France.

Market Access Launch Preparation Infectious Disease

Rotavirus Vaccination and Herd Effect: Budget Impact in Germany

Journal: Eur J Health Econ
Authors Karmann A, Jurack A, Lukas D

Budget impact analysis of rotavirus vaccination recommendation in Germany incorporating herd immunity effects.

Market Access Launch Preparation Oncology & Hematology

Health Economic Analysis of HPV Vaccines in Chile

Journal: BMC Public Health
Authors Gomez J, Lepetic A, Demarteau N

Markov model-based economic evaluation of HPV vaccination in Chilean women from healthcare payer perspective.

Insight Acceleration Post-Launch Lifecycle Cardiovascular & Metabolic Infectious Disease

Pneumonia and Influenza Hospital Admissions in Belgium

Journal: Arch Public Health
Authors Crott R, Pouplier I, Roch I, et al.

Retrospective database study analyzing respiratory and circulatory hospital admission patterns in Belgium.

Insight Acceleration Post-Launch Lifecycle Infectious Disease

Hospital-Based Surveillance of Rotavirus Burden in Romania

Journal: GERMS
Authors Anca I, Furtunescu F, Plesca D, et al.

Hospital surveillance study estimating rotavirus gastroenteritis burden in Romanian children under 5.

Clinical Strategy & Evidence Post-Launch Lifecycle Infectious Disease

Primary vs Secondary Failure After Varicella Vaccination

Journal: Pediatr Infect Dis J
Authors Bonanni P, Gershon A, Gershon M, et al.

Examines mechanisms and patterns of primary versus secondary vaccine failure following varicella vaccination.

Insight Acceleration Post-Launch Lifecycle Infectious Disease

Burden of Rotavirus Gastroenteritis in Greece

Journal: BMJ Open
Authors Konstantopoulos A, Tragiannidis A, Fouzas S, et al.

Prospective hospital-based surveillance study quantifying rotavirus burden in Greek children under 5.

Insight Acceleration Post-Launch Lifecycle Infectious Disease

Burden of Rotavirus Gastroenteritis in Japan

Journal: BMC Pediatr
Authors Tajiri H, Takeuchi Y, Takano T, et al.

Retrospective multicenter survey examining rotavirus gastroenteritis in Japanese children under 6 years.

Insight Acceleration Post-Launch Lifecycle Infectious Disease

Seroprevalences of Varicella-Zoster Virus in Mexico

Journal: Vaccine
Authors Conde-Glez C, Lazcano-Ponce E, Rojas R, et al.

Cross-sectional seroprevalence study of varicella-zoster virus, HSV, and CMV in Mexican populations.

Insight Acceleration Post-Launch Lifecycle Oncology & Hematology

HPV Type Distribution in Invasive Cervical Cancer Across Asia

Journal: Int J Gynecol Cancer
Authors Quek SC, Lim BK, Domingo E, et al.

Multi-country study examining HPV type distribution in invasive cervical cancer across 5 Asian countries.

Insight Acceleration Post-Launch Lifecycle Oncology & Hematology

HPV Prevalence in Cervical Adenocarcinoma in Korean Women

Journal: Gynecol Oncol
Authors Park JS, Kim YT, Lee A, et al.

Epidemiological study determining HPV prevalence and type distribution in Korean cervical adenocarcinoma.

Market Access Launch Preparation Infectious Disease

Health Economic Impact of Pneumococcal Vaccines in Hong Kong

Journal: Value Health
Authors Lee K, Wu D, Topachevskyi O, et al.

Economic analysis comparing 10-valent versus 13-valent pneumococcal conjugate vaccines in Hong Kong.

Clinical Strategy & Evidence Post-Launch Lifecycle Infectious Disease

Persistence and Immune Memory to Hepatitis B Vaccine

Journal: Hum Vaccines Immunother
Authors Poovorawan Y, Chongsrisawat V, Theamboonlers A, et al.

Long-term study examining hepatitis B vaccine persistence 20 years post-vaccination in Thai infants.

Insight Acceleration Post-Launch Lifecycle Oncology & Hematology

HPV Type Distribution in Cervical Lesions in Venezuelan Women

Journal: Gynecol Oncol
Authors Correnti M, Medina F, Cavazza M, et al.

Characterizes HPV type distribution across cervical carcinoma and squamous intraepithelial lesions in Venezuela.

Our insights reveal the integrated thinking behind breakthrough execution. Drawing from real-world project experience, conference observations, and healthcare innovation trends across clinical development, regulatory strategy, and market access, we share perspectives on how integrated approaches deliver faster, more credible outcomes.

LIVING SYSTEMATIC LITERATURE REVIEWS
Phase I/II Clinical Phase III Clinical Launch Preparation Post-Launch Lifecycle

LIVING SYSTEMATIC LITERATURE REVIEWS

Most healthcare innovators commission their systematic literature review 12 months before launch—when protocols are locked and evidence gaps can't be filled. Living SLRs change this paradigm.Starting in Phase 2 with biannual updates, they extract multi-dimensional intelligence (KOL networks, site mapping, treatment pathways, I/E criteria) that informs protocol development, regulatory strategy, and market access planning. This PRISMA 2020-aligned methodology transforms SLRs from static reports into dynamic knowledge repositories—enabling strategic PICOS evolution, evidence traceability for HTA submissions, and continuous adaptation to competitive landscapes throughout the molecule-to-market journey.

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Explore how we connect evidence, regulation, and access from the start to create competitive advantage and accelerate patient impact.